This Project titled “Architectural and Structural Design of Three-storey Clinic in Kisii District: addresses the pressing need for modern infrastructure in Kisii, particularly in meeting the growing demands of the hospitality industry. Given Kisii’s socio-economic landscape, where the tourism and hospitality sectors are pivotal for economic growth, this study aims to evaluate and create a sustainable architectural framework and structural design for a hotel that integrates modern design principles and sustainability. Problem Statement: As Kisii advances towards its vision for sustainable development, there is a critical requirement for infrastructures, such as hotels, that cater to the influx of tourists while promoting local economic growth. This study seeks to address the gap in architectural and structural frameworks within the hospitality sector, particularly in densely populated regions like Kisii District. Objectives: The primary objective of this study is to design a comprehensive architectural model and structural configuration for a three-storey Clinic, aiming for efficiency, safety, and aesthetic appeal. The specific objectives include: This study adopted a case study methodology focusing on Kisii District. Data was collected through site observations and analysis of the existing infrastructure. Architectural designs were rendered using ARCHICAD, while structural designs—including slabs, beams, columns, and foundations—were analyzed using PROKON software. Reinforcement specifications were calculated for each structural element to ensure safety and durability. The architectural design emphasized the integration of modern aesthetics with functional spaces, including reception areas, guest accommodations, and service rooms. The structural analysis revealed that the designed building could effectively support anticipated live and dead loads while maintaining safety standards. Recommendation: It is recommended that further research focuses on environmental impacts and how to incorporate renewable energy practices into clinic designs. Additionally, policymakers should facilitate training programs for civil engineering students to enhance competencies in using modern design software, which is crucial for sustainable infrastructure development in Kisii.