This project attempted to identify the effects of computer literacy on the job performance of modern secretaries and to find out if secretaries without computer knowledge can be conveniently employed in a modern office. The researcher used all the secretaries and some administrative staffs in Kisii Government Secretariat which is 75 staffs as the population of the study. However, because of the smallest of the population size, the researcher used the entire population of secretariat for the study. The instrument used for data collection was a 20-item structured questionnaire called ECLOSEC (effects of computer literacy on secretaries) which was prepared by the researcher. The researcher in order to get the needed result distributed questionnaire to some staff of the CountyGovernment secretariat which was the area of study of this project, and their responses were converted. The researcher was able to found out that there are some effects of computer literacy on modern secretaries which are speed and accuracy, neatness, easy edition, formatting and saving of documents. Also that secretary without computer knowledge cannot be employed in a modern office. Furthermore, the researcher agreed that the major problem of secretaries is the fear that computer has come to replace them because they know fully well that without computer knowledge they would not be able to do their work perfectly in a modern office. The researcher noticed that students are not taught word processing as a serious course and this has contributed to their failure in performing their job. It was as a result of these findings, the researcher suggested that every secretary should try hard to become computer literate by going for the training so as to secure gainful employment in a modern office.