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Sickle cell Crisis
| Institution | Kenya Medical Training College |
| Course | DIPLOMA IN NURSING |
| Year | 1st Year |
| Semester | Unknown |
| Posted By | stephen oyake rabilo |
| File Type | |
| Pages | 47 Pages |
| File Size | 833.89 KB |
| Views | 1946 |
| Downloads | 0 |
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Description
Sickle cell disease (SCD)
• A group of hereditary disorders in which the normal adult hemoglobin (hemoglobin A) is partly or completely replaced by abnormal sickle hemoglobin (HgbS).
• The most common genetic hematologic condition in children
• Transmitted by autosomal recessive pattern of inheritance.
• Patient with this condition is homozygous for the sickle cell gene, i.e. both genes are abnormal.
• The basic defect responsible for the sickling of
erythrocytes is contained in the globin fraction of hemoglobin
• The mode of transmission is hereditary
• The gene that determines the production of HgbS is situated on an autosome.
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