Python basics involve understanding its simple and readable syntax, which makes it accessible to beginners. Key concepts include variables, data types (such as integers, strings, and lists), and control flow structures like conditionals (if-else) and loops (for, while). Functions are used to organize code into reusable blocks, and Python also allows for easy error handling with try-except statements. The language's versatile nature supports multiple programming paradigms, including procedural, object-oriented, and functional programming, making it a powerful tool for tasks ranging from web development to data analysis and machine learning.