Creating an Android app with Android Studio involves several key steps. First, you need to download and install Android Studio, which includes all necessary tools like the Android SDK and emulator. After opening Android Studio, start a new project by selecting a template that fits your app's needs. You'll write code in Java or Kotlin, using XML to design the app's user interface (UI). The layout is built using various UI components such as buttons, text fields, and images. Once the app's structure is complete, you can test it using the emulator or a physical device. Debugging and refining your app ensures that it runs smoothly. Finally, once the app is polished, you can generate the APK (Android Package) file and distribute it through the Google Play Store or other means.